Structure of PDB 6y9h Chain H Binding Site BS03

Receptor Information
>6y9h Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6y9h Thrombin in complex with D-Phe-Pro-m-Trifluoromethylbenzylamide derivative (phe2)
Resolution1.48 Å
Binding residue
(original residue number in PDB)		H57 Y60A W60D N98 L99 D189 A190 E192 S195 S214 W215 G216 G219
Binding residue
(residue number reindexed from 1)		H43 Y47 W50 N95 L96 D192 A193 E195 S198 S219 W220 G221 G223
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6y9h, PDBe:6y9h, PDBj:6y9h
PDBsum6y9h
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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