Structure of PDB 1nrs Chain H Binding Site BS03

Receptor Information
>1nrs Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FG
Ligand information
Receptor-Ligand Complex Structure
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PDB1nrs Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		F34 R73 T74 R75 Y76 I82 M84
Binding residue
(residue number reindexed from 1)		F19 R68 T69 R70 Y71 I78 M80
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrs, PDBe:1nrs, PDBj:1nrs
PDBsum1nrs
PubMed8136362
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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