Structure of PDB 1eb1 Chain H Binding Site BS03

Receptor Information
>1eb1 Chain H (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB1eb1 The Methyl Group of N(Alpha)(Me)Arg-Containing Peptides Disturbs the Active-Site Geometry of Thrombin, Impairing Efficient Cleavage
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H57 Y60A W60D E97A N98 D189 A190 E192 G193 S195 S214 W215 G216 G219
Binding residue
(residue number reindexed from 1)		H43 Y47 W50 E94 N95 D199 A200 E202 G203 S205 S226 W227 G228 G230
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1eb1, PDBe:1eb1, PDBj:1eb1
PDBsum1eb1
PubMed11884127
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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