Structure of PDB 8adl Chain G Binding Site BS03

Receptor Information
>8adl Chain G (length=786) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLIKKVTHWSYDNLIDYLSVNPTRDEVTHYKVDPENESDESIIKLHTVKD
FGSITCLDYSESEIGMIGVGEKNGYLRIFNISYDIRVRAKKQRCINSLGI
NTNGLIAMGLDRNKHDSSLQIWDMNYHDDSHETINPMFSYCTNESIVSLK
FLNDTSVLAASTKFLKEIDVRSPNPIYQHPTRLTYDIKLNPFNDWQFSTY
GDDGTLAIWDRRKLSDASPLLTFEKLVGSGAASRKYMNSCFRWSCVRNNE
FATLHRGDTIKRWRLGYYCDSNIENLFVSSVHDTNTMYDRVATFDYIPRS
NNGTSLICMRQSGTIYRMPISEVCSKAILNNRNSLLLSNFENTEIDEIRV
NFWKPEKLLEKDISVIMRTRASLGYGLDPMNTVEMIDSSKQNNAYIRNTW
RWIAIAKASVDDGTMVSGDLDLGYEGVIGIWNGILSDKQLNKEMEKIIKL
RRKGSPKYVQRRLCLIISGWDLSRSDYEDKYNIIMKNGHYEKAAAWAVFF
GDIPKAVEILGSAKKERLRLIATAIAGYLAYKDLPGNNAWRQQCRKMSSE
LDDPYLRVIFAFIADNDWWDILYEPAISLRERLGVALRFLNDTDLTTFLD
RTSSTVIENGELEGLILTGITPNGIDLLQSYVNKTSDVQSAALISIFGSP
RYFRDQRVDEWIQTYRDMLKSWELFSMRARFDVLRSKLSRTKTGVLTADI
KPRQIYIQCQNCKQNINTPKYCCPHCGSSFPRCAICLMPLGTSKLKLNEW
FSFCLSCNHGMHAGHAEEWFDRHNVCPTPGCTCQCN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8adl Chain G Residue 1103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8adl Cryo-EM structure of the SEA complex.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		C1005 C1008 C1034
Binding residue
(residue number reindexed from 1)		C754 C757 C783
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0015031 protein transport
GO:1903432 regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0035859 Seh1-associated complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8adl, PDBe:8adl, PDBj:8adl
PDBsum8adl
PubMed36289347
UniProtP38164|SEA4_YEAST SEH-associated protein 4 (Gene Name=SEA4)

[Back to BioLiP]