Structure of PDB 7yo1 Chain G Binding Site BS03

Receptor Information
>7yo1 Chain G (length=879) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTWMTSVKDWAGV
MISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQID
MAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSW
LGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFI
HLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLF
MVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITL
ESVSNFLKAFLHKARDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQG
SVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPK
IRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGL
STMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTV
CELCFVKLKLLMISRILINPGNGTLGFFIASDAKEVKRAFFYCKKYDSTG
MFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMP
LRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLR
AVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDTTGVNIP
IITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSAT
YFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRV
AQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQ
CTKRYVITNPPYEFELVPTDLIFCLMQFD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7yo1 Chain G Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yo1 Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex
Resolution3.6 Å
Binding residue
(original residue number in PDB)		N509 S512 R514 V532 N534
Binding residue
(residue number reindexed from 1)		N456 S459 R461 V479 N481
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yo1, PDBe:7yo1, PDBj:7yo1
PDBsum7yo1
PubMed
UniProtQ12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

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