Structure of PDB 7wld Chain G Binding Site BS03

Receptor Information
>7wld Chain G (length=583) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVRRRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMG
STMVEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQ
SFSRKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTN
SQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTG
MQSSPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQ
TFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSH
GLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQS
FFLYLLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEASLVAPLL
ISQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNT
HRPDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPH
GPRTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQG
VLEHHTYGALLFPLLSLGLYPCWLLFWNVLFWK
Ligand information
Ligand IDBJR
InChIInChI=1S/C42H84NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h40H,6-39H2,1-5H3/p+1/t40-/m1/s1
InChIKeyPZNPLUBHRSSFHT-RRHRGVEJSA-O
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.6CCCCCCCCCCCCCCCCCC(=O)O[C@H](COC(=O)CCCCCCCCCCCCCCC)COP(=O)(O)OCC[N+](C)(C)C
ACDLabs 12.01O(C(COP(=O)(O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC)C(CCCCCCCCCCCCCCCCC)=O
CACTVS 3.385CCCCCCCCCCCCCCCCCC(=O)O[C@H](COC(=O)CCCCCCCCCCCCCCC)CO[P](O)(=O)OCC[N+](C)(C)C
OpenEye OEToolkits 2.0.6CCCCCCCCCCCCCCCCCC(=O)OC(COC(=O)CCCCCCCCCCCCCCC)COP(=O)(O)OCC[N+](C)(C)C
CACTVS 3.385CCCCCCCCCCCCCCCCCC(=O)O[CH](COC(=O)CCCCCCCCCCCCCCC)CO[P](O)(=O)OCC[N+](C)(C)C
FormulaC42 H85 N O8 P
Name(4S,7R)-7-[(hexadecanoyloxy)methyl]-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-3,5,8-trioxa-4lambda~5~-phosphahexacosan-1-aminium
ChEMBL
DrugBank
ZINCZINC000032792138
PDB chain7wld Chain G Residue 1604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wld Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		C512 T516 L598
Binding residue
(residue number reindexed from 1)		C474 T478 L560
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003923 GPI-anchor transamidase activity
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0034235 GPI anchor binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006506 GPI anchor biosynthetic process
GO:0006621 protein retention in ER lumen
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
GO:0065003 protein-containing complex assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0042765 GPI-anchor transamidase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wld, PDBe:7wld, PDBj:7wld
PDBsum7wld
PubMed35551457
UniProtO43292|GPAA1_HUMAN Glycosylphosphatidylinositol anchor attachment 1 protein (Gene Name=GPAA1)

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