Structure of PDB 6xh8 Chain G Binding Site BS03

Receptor Information

>6xh8 Chain G (length=130) Species: 562 (Escherichia coli)

MNISDVAKITGLTSKAIRFYEEKGLVTPPMRSENGYRTYTQQHLNELTLL
RQARQVGFNLEESGELVNLFNDPQRHSADVKRRTLEKVAEIERHIEELQS
MRDQLLALANACPGDDSADCPIIENLSGCC

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 6xh8 Chain G Residue 200

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xh8 Structural basis of copper-efflux-regulator-dependent transcription activation.
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): C120 P121
• Binding residue (residue number reindexed from 1): C120 P121
• Annotation score: 3

Gene Ontology

Molecular Function

• GO:0000976 transcription cis-regulatory region binding
• GO:0000987 cis-regulatory region sequence-specific DNA binding
• GO:0001216 DNA-binding transcription activator activity
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0005507 copper ion binding
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006355 regulation of DNA-templated transcription
• GO:0045893 positive regulation of DNA-templated transcription

Cellular Component

• GO:0005737 cytoplasm
• GO:0032993 protein-DNA complex

External links

• PDB: RCSB:6xh8, PDBe:6xh8, PDBj:6xh8
• PDBsum: 6xh8
• PubMed: 34113812
• UniProt: P0A9G4|CUER_ECOLI HTH-type transcriptional regulator CueR (Gene Name=cueR)