Structure of PDB 7yq5 Chain F Binding Site BS03

Receptor Information
>7yq5 Chain F (length=828) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPK
LIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKE
LGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNE
ECGDICPNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHS
ECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQ
DLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGL
IEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQ
LWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALK
TNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEA
PYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ
IILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPKTDSQI
LKELEESSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHFTGY
RIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVH
LMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSP
GNYSVRIRATSLAGNGSWTEPTYFYVTD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yq5 Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Resolution4.27 Å
Binding residue
(original residue number in PDB)		R14 L37 F39 R65 Y67 F88 F89 F96
Binding residue
(residue number reindexed from 1)		R11 L34 F36 R62 Y64 F85 F86 F93
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:7yq5, PDBe:7yq5, PDBj:7yq5
PDBsum7yq5
PubMed36310231
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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