Structure of PDB 7yq3 Chain F Binding Site BS03

Receptor Information
>7yq3 Chain F (length=831) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPK
LIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKE
LGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNE
ECGDICPNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHS
ECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQ
DLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGL
IEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQ
LWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALK
TNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEA
PYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQ
IILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLCSCPKTD
SQILKELEESSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISGLRHF
TGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENN
VVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRG
LSPGNYSVRIRATSLAGNGSWTEPTYFYVTD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yq3 Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R86 R271 Q272 G273 C274 H275 S323 T325 N348
Binding residue
(residue number reindexed from 1)		R83 R261 Q262 G263 C264 H265 S313 T315 N338
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:7yq3, PDBe:7yq3, PDBj:7yq3
PDBsum7yq3
PubMed36310231
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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