Structure of PDB 7u6e Chain F Binding Site BS03

Receptor Information
>7u6e Chain F (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLG
LIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLR
QLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL
KTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKE
APYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPW
TQYAIFVKTLVTFSTYGAKSDIIYVQTDASQILKELEESSFRKTFEDYLH
NVVFVPRP
Ligand information
>7u6e Chain G (length=19) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSLEEEWAQIECEVYGRCP
Receptor-Ligand Complex Structure
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PDB7u6e Activation of the human insulin receptor by non-insulin-related peptides
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R479 S481 K484 L486 R488 P537 L538 N547 G550 W551 L552 R554
Binding residue
(residue number reindexed from 1)		R170 S172 K175 L177 R179 P228 L229 N238 G241 W242 L243 R245
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7u6e, PDBe:7u6e, PDBj:7u6e
PDBsum7u6e
PubMed36171189
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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