Structure of PDB 7npa Chain F Binding Site BS03

Receptor Information
>7npa Chain F (length=618) Species: 523845 (Methanothermococcus thermolithotrophicus DSM 2095) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MYEWKLNDIVDNGICAKCGTCTVVCPNGILTFEDRPKLTEECLRKGNGMC
FEVCPRVSSGKYQIKIREKFKEEYYYGKGDVEGQDGGVVTTFLKYLLKNK
KIDGAIVVGDECWKPVSLIVQNEEDLMNTTKSKYTVSTLEALKTAGEMGL
EKVAVVGLPCQINGLRKLQYFQYLAKHDGELGKNGKPVKLPKIEYLIGLL
CTEKFEYDELKETLAKYNINMDDVEKFDIKKGKLLVYVNGEEHKIPLKEI
ELSAGCKMCRDFDAEMADVSVGCVGSPDGYSTVIIRTEKGEEIKNAIELK
EGVNLEAIEKLRDLKLNRFKKEVERRKAEDEKVSFYWTADYGGVGKRADG
TYFIRIRAKPAGWYSIDEAREILEIAEKYDGKIKMTNRGAFEIHGISGFD
VEAMVLELMEKGFITGSEGPLVRATLACPGEGNCGSGLINTTELCKILED
NFKEHPAPYKFKIAISGCPNKCVRPQIHDIGIAGVKFPVVNEENCNGCGR
CAEVCKIEAIDIRGETSYTNYNVCIGCGKCIKACPNEGRDVKEEGFMVYV
GGKTGREVIEGVSMKLMSVEEILNLIDKVLIVYHKYAKKPQRERLAAVMA
RIGKGKFLEEVKELMEQN
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7npa Chain F Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7npa Structures of the sulfite detoxifying F 420 -dependent enzyme from Methanococcales.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		C25 I29 L30 C42 R44 G46 G48 C50 E180
Binding residue
(residue number reindexed from 1)		C25 I29 L30 C42 R44 G46 G48 C50 E180
Annotation score1
Enzymatic activity
Enzyme Commision number 1.8.98.3: sulfite reductase (coenzyme F420).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0052592 oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor

View graph for
Molecular Function
External links
PDB RCSB:7npa, PDBe:7npa, PDBj:7npa
PDBsum7npa
PubMed36658338
UniProtA0A2Z5PF12

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