Structure of PDB 7mqo Chain F Binding Site BS03

Receptor Information

>7mqo Chain F (length=602) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVN
FSFCQDLHHKCKNSRCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVK
TLVTFSDERRTYGAKSDIIYVQTDQILKELEESSFRKTFEDYLHNVVFVP
RP

Ligand information

>7mqo Chain D (length=18) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NQHLCGSELVEALYLVCL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7mqo Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Resolution	3.4 Å
Binding residue (original residue number in PDB)	F39 R65
Binding residue (residue number reindexed from 1)	F39 R65

Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

External links

PDB	RCSB:7mqo, PDBe:7mqo, PDBj:7mqo
PDBsum	7mqo
PubMed	35289328
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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