Structure of PDB 6xl9 Chain F Binding Site BS03

Receptor Information
>6xl9 Chain F (length=465) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAI
TYLLEQYDRVENSIDPELAREKFAELRAQYVVTRDTIKAKGRSHATAQEE
ILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMP
KKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIE
EETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRG
LQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQAR
TIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVL
KIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDVL
AGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKL
RHPSRSEVLRSFLDD
Ligand information
Ligand ID118
InChIInChI=1S/4C6H5.Sb/c4*1-2-4-6-5-3-1;/h4*1-5H;/q;;;;+1
InChIKeySZOUUWBVOLRGQM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04c1c(cccc1)[Sb+](c2ccccc2)(c3ccccc3)c4ccccc4
CACTVS 3.341
OpenEye OEToolkits 1.5.0		c1ccc(cc1)[Sb+](c2ccccc2)(c3ccccc3)c4ccccc4
FormulaC24 H20 Sb
NameTETRAPHENYLANTIMONIUM ION
ChEMBL
DrugBank
ZINC
PDB chain6xl9 Chain F Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6xl9 Structural visualization of transcription activated by a multidrug-sensing MerR family regulator.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		W433 R436 Q437
Binding residue
(residue number reindexed from 1)		W285 R288 Q289
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xl9, PDBe:6xl9, PDBj:6xl9
PDBsum6xl9
PubMed33976201
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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