Structure of PDB 4q0z Chain F Binding Site BS03

Receptor Information

>4q0z Chain F (length=307) Species: 559292 (Saccharomyces cerevisiae S288C)

GVHSFWDIAGPTARPVRLESLEDKRMAVDASIWIYQFLKAVRAVKNSHIT
GFFRRICKLLYFGIRPVFVFDGGVPVLKRETIRQRKERDEVTMDMIKEVQ
ELLSRFGIPYITAPMEAEAQCAELLQLNLVDGIITDDSDVFLFGGTKIYK
NMFHEKNYVEFYDAESILKLLGLDRKNMIELAQLLGSDYTNGLKGMGPVS
SIEVIAEFGNLKNFKDWYNNGQFDKRKQETENKFEKDLRKKLVNNEIILD
DDFPSVMVYDAYMRPEVDHDTTPFVWGVPDLDMLRSFMKTQLGWPHEKSD
EILIPLI

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4q0z Chain F Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4q0z Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
• Resolution: 2.398 Å
• Binding residue (original residue number in PDB): E794 D813 D864
• Binding residue (residue number reindexed from 1): E118 D137 D188
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003697 single-stranded DNA binding
• GO:0003824 catalytic activity
• GO:0004518 nuclease activity
• GO:0004519 endonuclease activity
• GO:0016788 hydrolase activity, acting on ester bonds

Biological Process

• GO:0006289 nucleotide-excision repair

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4q0z, PDBe:4q0z, PDBj:4q0z
• PDBsum: 4q0z
• PubMed: 25120270
• UniProt: P07276|RAD2_YEAST DNA repair protein RAD2 (Gene Name=RAD2)