Structure of PDB 4p0s Chain F Binding Site BS03

Receptor Information
>4p0s Chain F (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAALVTRMKAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVI
EAQAVPCSVTWRRRAGPSEDREDWVEEPTVLVLLRAEAFVSMIDNGKTLQ
GFVTDITAKTAGKALSLVIVDQEKCFVSRVDAEEALVDLQLHTEAQAQIV
QSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGR
GLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNL
LADIQVRRTSRRIGPELSRRIYLQMTTLQPHLSL
Ligand information
Receptor-Ligand Complex Structure
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PDB4p0s Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Resolution6.0 Å
Binding residue
(original residue number in PDB)		S463 R491 V492 S493 M496 T541
Binding residue
(residue number reindexed from 1)		S187 R215 V216 S217 M220 T259
Enzymatic activity
Enzyme Commision number 3.1.22.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus
GO:0048476 Holliday junction resolvase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p0s, PDBe:4p0s, PDBj:4p0s
PDBsum4p0s
PubMed24733841
UniProtQ96AY2|EME1_HUMAN Crossover junction endonuclease EME1 (Gene Name=EME1)

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