Structure of PDB 4iqr Chain F Binding Site BS03

Receptor Information
>4iqr Chain F (length=314) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKD
KRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQ
AEVLSRSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPL
DDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSR
VSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRS
QVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGM
AKIDNLLQEMLLGG
Ligand information
Receptor-Ligand Complex Structure
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PDB4iqr Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K194 L204 Q207 R212 L360 E363 M364
Binding residue
(residue number reindexed from 1)		K140 L150 Q153 R158 L306 E309 M310
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iqr, PDBe:4iqr, PDBj:4iqr
PDBsum4iqr
PubMed23485969
UniProtP41235|HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (Gene Name=HNF4A)

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