Structure of PDB 9bs3 Chain E Binding Site BS03

Receptor Information

>9bs3 Chain E (length=487) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVE
TLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRD
IARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVL
AALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEV
PDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEE
AAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKL
PSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEF
LEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKK

Ligand information

>9bs3 Chain H (length=18) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gtccgaccacgcatcagc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9bs3 Structures of LIG1 uncover the mechanism of sugar discrimination against 5'-RNA-DNA junctions during ribonucleotide excision repair.
Resolution	2.69 Å
Binding residue (original residue number in PDB)	R305 T415 G416 A418 T420 R451 G453 A455 Q457 S458 R557 Q636 T639 T640 K642 R643 H740
Binding residue (residue number reindexed from 1)	R45 T155 G156 A158 T160 R191 G193 A195 Q197 S198 R297 Q376 T379 T380 K382 R383 H480

External links

PDB	RCSB:9bs3, PDBe:9bs3, PDBj:9bs3
PDBsum	9bs3
PubMed	39159820
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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