Structure of PDB 8wwu Chain E Binding Site BS03

Receptor Information

>8wwu Chain E (length=488) Species: 1615674 (Pseudomonas lactis)

DFITKNNLWTNEQRDAADKVLAEIDSLGLEMIRLSWADQYGLLRGKSLTV
ASLKSAFKEGSEVAIGPFFFDLVSSMVFNLFTTAFEDELSGNPTVVMVPD
PTTFKVLPWADKTGWMLADLHWKSGEPFPLCPRGIMKKAVKSLSDEGYLF
KCGIELEWYLTKIVDRSLSPESLGAPGVQPDAIQVQPVAQGYSVLLEHHL
DQVDDIMSKVRKGLLELNLPLRSIEDEWAPSQMETTFDVMEGLEAADAAL
LIKSAIKQICSRHGYHATFMCKPAINGFFASGWHMHQSLVDKDTRKNLFI
PSEGEVLSPLGRAYAGGLLANGSAASSFTTPTVNGYRRRQPYSLAPDRRA
WAKDNKAAMVRVVSATGDPASRIENRIGEPGANPYLYMASQIVSGLDGIK
NKKDPGELQESPYDAQVPMLPTTLAEALDALEHDSELFRSCFGDTFIKYW
LQLRRSEWARFLDAEGAEAAEPTGAVTQWEQKEYFNLL

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 8wwu Chain E Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8wwu Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): E162 H291 E381
• Binding residue (residue number reindexed from 1): E155 H284 E374
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0016879 ligase activity, forming carbon-nitrogen bonds
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0016020 membrane

External links

• PDB: RCSB:8wwu, PDBe:8wwu, PDBj:8wwu
• PDBsum: 8wwu
• UniProt: A0A7Y1Q2L1