Structure of PDB 8twa Chain E Binding Site BS03

Receptor Information

>8twa Chain E (length=1123) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKD
IDQIPGRVGWLTNMHATLVSGISGVDFYFLDEEGGSFKSTVVYDPYFFIA
CNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLS
FVNSNQLFEARKLLRPILQDNANNDAKHLIEDIREYDVPYHVRVSIDKDI
RVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIM
MISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALL
QRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAE
GEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELM
TPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLR
KGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE
SLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTN
FEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSI
KAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETF
PNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVERE
AIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEA
KKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQ
MARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSM
LNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSK
EEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEG
DTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEY
EGQKSTSITTARRLGDFLKGLQCKYIISSKPFNAPVTERAIPVAIFSADI
PIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQG
VSNPVPRVEHPDWLKRKIATKED

Ligand information

>8twa Chain T (length=15) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tttttagcagcaaca

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8twa Cryo-EM reveals that Ctf18-RFC collaborates with PolE to load the PCNA clamp onto a leading strand DNA
Resolution	4.1 Å
Binding residue (original residue number in PDB)	E409 T512 G513 T514 Y553 V554 G555 G556 R686 G832 M835 R836 K966 K967
Binding residue (residue number reindexed from 1)	E350 T453 G454 T455 Y494 V495 G496 G497 R627 G773 M776 R777 K907 K908

External links

PDB	RCSB:8twa, PDBe:8twa, PDBj:8twa
PDBsum	8twa
PubMed
UniProt	P21951\|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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