Structure of PDB 8tp1 Chain E Binding Site BS03

Receptor Information

>8tp1 Chain E (length=419) Species: 10090 (Mus musculus)

MPFSDFVLALKDNPYFGAGFGLVGVGTALAMARKGAQLGLVAFRRHYMIT
LEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPS
PGNHFIWYQGKWIRVERNRDMQMVDLQTGTPWESVTFTALGTDRKVFFNI
LEEARALALQQEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADR
IVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHS
ICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPIK
YQGLGRLTFSGLLNALDGVASTEARIVFMTTNYIDRLDPALIRPGRVDLK
EYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLKATSEISPAQVQGYF
MLYKNDPMGAVHNIESLRP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8tp1 Chain E Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8tp1 Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate.
• Resolution: 3.02 Å
• Binding residue (original residue number in PDB): S237 E282
• Binding residue (residue number reindexed from 1): S237 E282
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0008566 mitochondrial protein-transporting ATPase activity
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0007005 mitochondrion organization
• GO:0032981 mitochondrial respiratory chain complex I assembly
• GO:0033617 mitochondrial cytochrome c oxidase assembly
• GO:0034551 mitochondrial respiratory chain complex III assembly
• GO:0071806 protein transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane

External links

• PDB: RCSB:8tp1, PDBe:8tp1, PDBj:8tp1
• PDBsum: 8tp1
• PubMed: 38821922
• UniProt: Q9CZP5|BCS1_MOUSE Mitochondrial chaperone BCS1 (Gene Name=Bcs1l)