Structure of PDB 8ovj Chain E Binding Site BS03

Receptor Information
>8ovj Chain E (length=186) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKVKSLCTLQIPEGVTVDVKGRKVTVTGKRGTLTKDLTHLQLDLRVDKKN
RTFTVIRWFGSKIPIACLNTTKAHVQNMITGVTKGYRFKVRCAYAHFPIN
VSVDGQNIEVRNFLGEKRVRRQLVPNTVKVSQTDPSKVKDEIVFDGNDLE
QVSREAAVLHQMCLVKKKDIRKFLDGIYVQTKTNIE
Ligand information
>8ovj Chain 2 (length=1105) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaug
cucugguacauagagaaagguacacucagggaagucggcaaaauagaugc
guaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucaga
acugcuuacggcggggaauccaacuguauaauuaaaacauagguuuguga
ugcauccaagugguguauaucgcaaacugauuucugcccagugcucugaa
ugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacu
augacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgc
augaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaa
cgacagucaagggaacggacuugaagggcuaagcggggaaagaagacccu
guugaguuugacuccagucuggcucugugcggcgacauccguugcuucac
uuaucgaaugaagagaccaauggguugcguagucuucgggcuaugcaccg
ucuagguuguggguacccaaccgugcuguaaacugaaccaacgggaguuc
cggagucuuguuucgagacaucugccagauggggaguuuggcuggggcgg
cauaucuguuacacgacaacgcagguguccuaaggcgagcucagugggaa
cagaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuc
caguacgaaucgagacugcgaaagcaaggccagcgauccuuugcgaagaa
uaggaaauaugaacaaaucauaccagaggugucagaauaauuaccacagg
gauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugau
ccuucgaugucggcucuuccuaaccuagcgccgcagaagacgcuaagggu
uggauuguucacccacugacagggaacgugagcuggguuuagaccgucgu
gagacagguugguuuuacccuacuuagcuggaaauugcgagaaaaagauu
auccgugcaaagcggacguggcgagcgguggguaguacaugguacgcuca
ucacc
.......................<<......>>......<<<<<...>>>
>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<
....<<..>>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>
.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<..
..<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....
<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<....
...>>>>>>........<...........<<<<<.......>>>>>....
.>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>......
......<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<
<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>
...<<<<<.....<<<<....<<...<<<<<<<<<..>>>>>>>>>.>>.
....<<<............>>>...................<<<<...>>
>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>
>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.
....>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.
......>>>>>..>>.<<<....>>>.>>.........<<<<<.......
.......<<<<.......>>>>.>>>>>..........>>>>..>>>>>>
.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>
.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.
<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<..
..>>>.>>>>....>>..>>>.>>>>>>>.....................
..<<<<.....>>>>.<<<.>>>.<.<<<<<<<.<<<<...>>>>>>>>>
>>.>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D170 R172 K173
Binding residue
(residue number reindexed from 1)		D169 R171 K172
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4QC91

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