Structure of PDB 8guy Chain E Binding Site BS03

Receptor Information
>8guy Chain E (length=835) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKD
DNEECGDICPCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCC
HSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSF
CQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKP
WTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSS
SQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSCSC
PKTDSQILKELEESSFRKTFEDYLHNVVFVPRPHRPFEKVVNKESLVISG
LRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEI
FENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGC
RLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTD
Ligand information
>8guy Chain D (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NQHLCGSHLVEALYLVCGERGFFYT
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8guy Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Resolution4.18 Å
Binding residue
(original residue number in PDB)		P495 F497 R498 R539 N541 R717
Binding residue
(residue number reindexed from 1)		P487 F489 R490 R531 N533 R682
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:8guy, PDBe:8guy, PDBj:8guy
PDBsum8guy
PubMed36310231
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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