Structure of PDB 8ebw Chain E Binding Site BS03

Receptor Information
>8ebw Chain E (length=355) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RWEGGYERTWEILKEEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLT
CTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLK
KAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPSNI
YDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELL
THHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEP
GLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQ
EIPLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCC
PGCIH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ebw Chain E Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ebw Lesion recognition by XPC, TFIIH and XPA in DNA excision repair.
Resolution5.6 Å
Binding residue
(original residue number in PDB)		C291 C305
Binding residue
(residue number reindexed from 1)		C259 C273
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0002031 G protein-coupled receptor internalization
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006351 DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0009411 response to UV
Cellular Component
GO:0000438 core TFIIH complex portion of holo TFIIH complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ebw, PDBe:8ebw, PDBj:8ebw
PDBsum8ebw
PubMed37076618
UniProtQ13888|TF2H2_HUMAN General transcription factor IIH subunit 2 (Gene Name=GTF2H2)

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