Structure of PDB 8e14 Chain E Binding Site BS03

Receptor Information
>8e14 Chain E (length=269) Species: 11888 (Rous sarcoma virus - Prague C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGV
NPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
VQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNS
QGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFE
RGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVK
NRDTDKVIWVPSRKVKPDI
Ligand information
>8e14 Chain L (length=42) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gagtattgcataagacaacagtgcacgaaagaagaagacact
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8e14 Molecular determinants for Rous sarcoma virus intasome assemblies involved in retroviral integration.
Resolution3.36 Å
Binding residue
(original residue number in PDB)		R95 V96 T97 S98 S128 K129
Binding residue
(residue number reindexed from 1)		R95 V96 T97 S98 S128 K129
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8e14, PDBe:8e14, PDBj:8e14
PDBsum8e14
PubMed37084813
UniProtP03354|POL_RSVP Gag-Pol polyprotein (Gene Name=gag-pol)

[Back to BioLiP]