Structure of PDB 7tid Chain E Binding Site BS03

Receptor Information
>7tid Chain E (length=338) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WVDKYRPKSLNALSHNEELTNFLKSLSDQPRDLPHLLLYGPNGTGKKTRC
MALLESIFGPGVYRLKIDVRQFVTASNRKLELNVVSSPYHLEITPSDMGN
NDRIVIQELLKEVAQMEHRYKCVIINEANSLTKDAQAALRRTMEKYSKNI
RLIMVCDSMSPIIAPIKSRCLLIRCPAPSDSEISTILSDVVTNERIQLET
KDILKRIAQASNGNLRVSLLMLESMALNNELALKSSSPIIKPDWIIVIHK
LTRKIVKERSVNSLIECRAVLYDLLAHCIPANIILKELTFSLLDVETLNT
TNKSSIIEYSSVFDERLSLGNKAIFHLEGFIAKVMCCL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7tid Chain E Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tid Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		V5 R9 P10 L16 S17 H18 N45 G46 G48 K49 K50 T51
Binding residue
(residue number reindexed from 1)		V2 R6 P7 L13 S14 H15 N42 G43 G45 K46 K47 T48
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tid, PDBe:7tid, PDBj:7tid
PDBsum7tid
PubMed35179493
UniProtP38251|RFC5_YEAST Replication factor C subunit 5 (Gene Name=RFC5)

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