Structure of PDB 7rpo Chain E Binding Site BS03

Receptor Information
>7rpo Chain E (length=439) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMEFKVIAEYFDKLEKISSRLQLTALLADLLSKSDKTIIDKVVYIIQGK
LWPDFLGYPELGIGEKFLIKAISIATNTDENSVENLYKTIGDLGEVARRL
KSKQQSTGILGFLGTTSKESLTVDEVYSTLSKVALTTGEGSRDLKIRLLA
GLLKKADPLEAKFLVRFVEGRLRVGIGDATVLDAMAIAFGGGQSASEIIE
RAYNLRADLGNIAKIIVEKGIEALKTLKPQVGIPIRPMLAERLSNPEEIL
KKMGGNAIVDYKYDGERAQIHKKEDKIFIFSRRLENITSQYPDVVDYVSK
YIEGKEFIIEGEIVAIDPESGEMRPFQELMHRKRKSDIYEAIKEYPVNVF
LFDLMYYEDVDYTTKPLEARRKLLESIVKPNDYVKIAHHIQANNVEDLKS
FFYRAISEGGEGVMVKAIGKDAIYQAGARGWLWIKLKRD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7rpo Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Resolution4.16 Å
Binding residue
(original residue number in PDB)		E137 R140 R171 G173 R332 K333
Binding residue
(residue number reindexed from 1)		E139 R142 R173 G175 R334 K335
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051301 cell division
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7rpo, PDBe:7rpo, PDBj:7rpo
PDBsum7rpo
PubMed34838188
UniProtQ980T8|DNLI_SACS2 DNA ligase (Gene Name=lig)

[Back to BioLiP]