Structure of PDB 7qtt Chain E Binding Site BS03

Receptor Information
>7qtt Chain E (length=198) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFK
RKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKV
RPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKKPGDL
SDELRISLGMPVPPPWLIAMQRYGPPPSYPNLKIPGLNSPLYGDVFGT
Ligand information
>7qtt Chain g (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucggccuccgaacgguaagagccuagcauguagaacugguuaugauguca
uacuuauccugucccuuuuuuuucca
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Receptor-Ligand Complex Structure
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PDB7qtt Structural basis of catalytic activation in human splicing.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K507 R508 K509
Binding residue
(residue number reindexed from 1)		K50 R51 K52
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qtt, PDBe:7qtt, PDBj:7qtt
PDBsum7qtt
PubMed37165190
UniProtQ13435|SF3B2_HUMAN Splicing factor 3B subunit 2 (Gene Name=SF3B2)

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