Structure of PDB 7mqs Chain E Binding Site BS03

Receptor Information

>7mqs Chain E (length=806) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEE
CGDICPGTNCPATQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLH
HKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEK
TIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLK
IRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNL
TITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCE
NELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVVVDI
DPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSD
IIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWER
QAEDSELFELDYCLKGLKLPSRQILKELEESSFRKTFEDYLHNVVFVPRE
EHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSAR
TMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGD
EELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFY
VTDYLD

Ligand information

>7mqs Chain H (length=18) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NQHLCGSELVEALYLVCL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7mqs Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Resolution	4.4 Å
Binding residue (original residue number in PDB)	P495 F497 R498 E706 H710 F714
Binding residue (residue number reindexed from 1)	P476 F478 R479 E638 H642 F646

Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

External links

PDB	RCSB:7mqs, PDBe:7mqs, PDBj:7mqs
PDBsum	7mqs
PubMed	35289328
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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