Structure of PDB 7kui Chain E Binding Site BS03

Receptor Information
>7kui Chain E (length=269) Species: 269446 (Rous sarcoma virus (strain Schmidt-Ruppin A)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGV
NPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
VQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNS
QGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFE
RGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVK
NRDTDKVIWVPSRKVKPDI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7kui Chain E Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7kui Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		H9 H13 C37
Binding residue
(residue number reindexed from 1)		H9 H13 C37
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:7kui, PDBe:7kui, PDBj:7kui
PDBsum7kui
PubMed33712691
UniProtP03354|POL_RSVP Gag-Pol polyprotein (Gene Name=gag-pol)

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