Structure of PDB 7jl2 Chain E Binding Site BS03

Receptor Information
>7jl2 Chain E (length=662) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKAS
EPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVV
KSCDIIISTAQILENSLLNLAGVQLSDFSLIIIDECHHTNKEAVYNNIMR
HYLMQKLKNNRLKKVIPLPQILGLTASPGVGGATKQAKAEEHILKLCANL
DAFTIKTVKENLDQLKNQIQEPCKKFAIADREDPFKEKLLEIMTRIQTYC
QMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQIND
TIRMIDAYTHLETFYNEEKDKKFAVIEETDRFLMTLFFENNKMLKRLAEN
PEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEK
FAEVGVKAHHLIGAGSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEE
GLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIERE
TVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAK
HYNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVREKQ
INGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVE
LPITFPNLDYSE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7jl2 Chain E Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7jl2 Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		C907 C910 C964
Binding residue
(residue number reindexed from 1)		C562 C565 C609
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:7jl2, PDBe:7jl2, PDBj:7jl2
PDBsum7jl2
PubMed33373584
UniProtQ9BYX4|IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (Gene Name=IFIH1)

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