Structure of PDB 6ywy Chain E Binding Site BS03

Receptor Information
>6ywy Chain E (length=309) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IPDLAELETRSALDAPIPSEEDKKEFRPWKRAADRKARLPSSRYQYHPPK
YNRGPLHPIQSPPSSDPIARDFVPGPFNMPRLKETFRTVMASDLMTLAYI
HTPPGTPKKEPTERLRAWEGDSPYFANRARRAPRGAPELPIRERDISFRN
IPEIKEITVSTFVPLGLKNPDLLIVARAVLLAMTGTMPEMTRSKNNVVQW
QLQANKPAGCKTTIYGNAAWEFMDRLIHLVLPRIKDWKGVPASTGDGSGN
VQFGLNPEDVQLFPEVECNYDMYPAKMIPGCHIAIKTTATSDRQAKLLLQ
SLGVPFYSN
Ligand information
Ligand IDNAD
InChIInChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChIKeyBAWFJGJZGIEFAR-NNYOXOHSSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](CO[P]([O-])(=O)O[P@](O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
OpenEye OEToolkits 1.5.0c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
CACTVS 3.341NC(=O)c1ccc[n+](c1)[CH]2O[CH](CO[P]([O-])(=O)O[P](O)(=O)OC[CH]3O[CH]([CH](O)[CH]3O)n4cnc5c(N)ncnc45)[CH](O)[CH]2O
OpenEye OEToolkits 1.5.0c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)([O-])O[P@@](=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
FormulaC21 H27 N7 O14 P2
NameNICOTINAMIDE-ADENINE-DINUCLEOTIDE
ChEMBLCHEMBL1234613
DrugBankDB14128
ZINC
PDB chain6ywy Chain 2 Residue 4301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ywy Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		P119 M122 K126 R130 N260
Binding residue
(residue number reindexed from 1)		P76 M79 K83 R87 N217
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ywy, PDBe:6ywy, PDBj:6ywy
PDBsum6ywy
PubMed33056988
UniProtQ96U12

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