Structure of PDB 6q2o Chain E Binding Site BS03

Receptor Information
>6q2o Chain E (length=572) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNHGFPLLTVYLKVFLS
CQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFH
QFRLLPVQFLCPNISVAYRLLGLPFRCAPDSLEVSTRWALDREQREKYEL
VAVCTVHEEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVV
ATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQAN
GSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSGVLLLHFNVSVLPV
SLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQL
LVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKG
ITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6q2o Chain E Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6q2o Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		D266 S268 D300 D302 Y314 D378
Binding residue
(residue number reindexed from 1)		D223 S225 D257 D259 Y271 D335
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6q2o, PDBe:6q2o, PDBj:6q2o
PDBsum6q2o
PubMed31535977
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

[Back to BioLiP]