Structure of PDB 6q2n Chain E Binding Site BS03

Receptor Information
>6q2n Chain E (length=553) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNHGFPLLTVYLKVFLS
GECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGT
FHQFRLLPVQFLCPNISVAYRLLGLPFRCAPDSLEVSTRWALDREQREKY
ELVAVCTVHEEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDT
VVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQ
ANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSVLLLHFNVSVLP
VSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSCSTL
GVVTSAEDTSGILFVNPKCAELHYMVVATDQQTSRQAQAQLLVTVEGCPL
SCAVSKRRLECEECGGLGSPTGRCEWRQGKGITRNFSTCSPSTKTCPDGH
CDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCF
CEP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6q2n Chain E Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6q2n Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		E178 D230 E232 D267
Binding residue
(residue number reindexed from 1)		E144 D193 E195 D226
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q2n, PDBe:6q2n, PDBj:6q2n
PDBsum6q2n
PubMed31535977
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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