Structure of PDB 6dt1 Chain E Binding Site BS03

Receptor Information
>6dt1 Chain E (length=459) Species: 10665 (Tequatrovirus T4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MILKILNEIASIGSTKQKQAILEKNKDNELLKRVYRLTYSRGLQYYIKKW
PKPGIATQSFGMLTLTDMLDFIEFTLATRKLTGNAAIEELTGYITDGKKD
DVEVLRRVMMRDLECGASVSIANKVWPGLIPEQPQMLASSYDEKGINKNI
KFPAFAQLKADGARCFAEVRGDELDDVRLLSRAGNEYLGLDLLKEELIKM
TAEARQIHPEGVLIDGELVYHVAESRTASNGIANKSLKGTISEKEAQCMK
FQVWDYVPLVEIYSLPAFRLKYDVRFSKLEQMTSGYDKVILIENQVVNNL
DEAKVIYKKYIDQGLEGIILKNIDGLWENARSKNLYKFKEVIDVDLKIVG
IYPHRKDPTKAGGFILESECGKIKVNAGSGLKDKAGVKSHELDRTRIMEN
QNYYIGKILECECNGWLKSDGRTDYVKLFLPIAIRLREDKTKANTFEDVF
GDFHEVTGL
Ligand information
Receptor-Ligand Complex Structure
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PDB6dt1 T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		R79 T82 N84 G116 S118 V119 S120 T255 G259 N262 K263 T268 K361 Y380 H382 R383 K384 G390 N404 G406 S407 S447 D448 R450 K455 L456 P459
Binding residue
(residue number reindexed from 1)		R79 T82 N84 G116 S118 V119 S120 T227 G231 N234 K235 T240 K333 Y352 H354 R355 K356 G362 N376 G378 S379 S419 D420 R422 K427 L428 P431
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:6dt1, PDBe:6dt1, PDBj:6dt1
PDBsum6dt1
PubMed30169742
UniProtP00970|DNLI_BPT4 DNA ligase (Gene Name=30)

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