Structure of PDB 5nsm Chain E Binding Site BS03

Receptor Information

>5nsm Chain E (length=519) Species: 185431 (Trypanosoma brucei brucei TREU927)

TLPKAEAKELSAFVQSCVEYKTNVCFTDVAAYESNQKGVLSSGLAVLVGT
HKQLRDPAVQRLPFYNPAVAEAIERVKEGGTYGVLVEGLANAAGSKFVRV
VVGEVPTKASRNNCPARPDVVTALVTAALDEVKEPNTTVDVFVLSNAVLP
IAAAVARCGKHNFSAKDGAAAAAYNSGKVSRLQVVFPEPPAIPPKDLEAV
ATSTQLCQRLVDAPPNLLTTATFTEIAQGYAKALGFDVDVICGDDLCERG
YGGIYSVGKAAFEAPRLVTLLYTPKGTPVKKVSLVGKGIVYDCGGLALKP
ADYMKLMKHDMGGAAAVFCGFLTAVRLQQPVQLSCTLCLAENAIGPKSYR
NDDIIVMKSGKTVEVINTDAEGRIVLGDGVFHATNELSFTPDVVIDMATL
TGAQGIATGRHHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPE
FKSNHADMTNLMERRDNAGVSCAGYFITTHLSPKFTGAHIHVDLAYPVFN
SNGATGFGPALLTEYFRKL

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5nsm Chain E Residue 603

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5nsm Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation inTrypanosoma brucei.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): K289 D294 D312 E373
• Binding residue (residue number reindexed from 1): K287 D292 D310 E371
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): K301 R375
• Catalytic site (residue number reindexed from 1): K299 R373

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0005515 protein binding
• GO:0008233 peptidase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5nsm, PDBe:5nsm, PDBj:5nsm
• PDBsum: 5nsm
• PubMed: 28815215
• UniProt: Q385B0