Structure of PDB 5m6c Chain E Binding Site BS03

Receptor Information
>5m6c Chain E (length=184) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFF
PYGDASKFAEHVFRNFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFS
MYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQM
DTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSST
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5m6c Chain E Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5m6c Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D109 D111 N113 Y115 E120
Binding residue
(residue number reindexed from 1)		D103 D105 N107 Y109 E114
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0014070 response to organic cyclic compound
GO:0019722 calcium-mediated signaling
GO:0048839 inner ear development
GO:0060041 retina development in camera-type eye
GO:0071257 cellular response to electrical stimulus
GO:0071277 cellular response to calcium ion
GO:0090314 positive regulation of protein targeting to membrane
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1901385 regulation of voltage-gated calcium channel activity
GO:1901986 response to ketamine
GO:1902065 response to L-glutamate
GO:1904010 response to Aroclor 1254
GO:1905232 cellular response to L-glutamate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030424 axon
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
GO:0032839 dendrite cytoplasm
GO:0043204 perikaryon
GO:0044327 dendritic spine head
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5m6c, PDBe:5m6c, PDBj:5m6c
PDBsum5m6c
PubMed28398555
UniProtP84074|HPCA_HUMAN Neuron-specific calcium-binding protein hippocalcin (Gene Name=HPCA)

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