Structure of PDB 5cfy Chain E Binding Site BS03

Receptor Information
>5cfy Chain E (length=411) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLK
MLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMAR
LFNPGAGIHLAVGGQQFQPKQAPPLVHILLDIVPTNPFGALANGQVLPTI
FFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYA
PIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYG
IDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPL
GATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGV
PGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGATMVNVTGD
LTGTAIVAKTE
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain5cfy Chain E Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5cfy Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		S278 G306 A307 N310 N401 D405
Binding residue
(residue number reindexed from 1)		S273 G301 A302 N305 N396 D400
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cfy, PDBe:5cfy, PDBj:5cfy
PDBsum5cfy
PubMed24842876
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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