Structure of PDB 3o8o Chain E Binding Site BS03

Receptor Information
>3o8o Chain E (length=752) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGG
KYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDA
LVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLV
GSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHC
GWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTII
VAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWL
ATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAI
ENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVG
APSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVEN
WHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQL
RDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQ
SASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIRED
ITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGV
RTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEEDDSAAVIC
VNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAE
VA
Ligand information
Ligand IDF6P
InChIInChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/t3-,4-,5+,6-/m1/s1
InChIKeyBGWGXPAPYGQALX-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCC1OC(O)(CO)C(O)C1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)OP(=O)(O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)OP(=O)(O)O
CACTVS 3.341OC[C]1(O)O[CH](CO[P](O)(O)=O)[CH](O)[CH]1O
CACTVS 3.341OC[C@@]1(O)O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@@H]1O
FormulaC6 H13 O9 P
Name6-O-phosphono-beta-D-fructofuranose;
FRUCTOSE-6-PHOSPHATE;
6-O-phosphono-beta-D-fructose;
6-O-phosphono-D-fructose;
6-O-phosphono-fructose
ChEMBLCHEMBL604196
DrugBank
ZINCZINC000004096690
PDB chain3o8o Chain F Residue 984 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3o8o The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R391 K482
Binding residue
(residue number reindexed from 1)		R189 K280
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) G215 R278 D309 S354 D356 D358 R400
Catalytic site (residue number reindexed from 1) G13 R76 D107 S152 D154 D156 R198
Enzyme Commision number 2.7.1.11: 6-phosphofructokinase.
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3o8o, PDBe:3o8o, PDBj:3o8o
PDBsum3o8o
PubMed21241708
UniProtP16861|PFKA1_YEAST ATP-dependent 6-phosphofructokinase subunit alpha (Gene Name=PFK1)

[Back to BioLiP]