Structure of PDB 3lsf Chain E Binding Site BS03

Receptor Information
>3lsf Chain E (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKNK
WWYDKGEC
Ligand information
Ligand IDPZI
InChIInChI=1S/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2,(H2,7,9)
InChIKeyGMZVRMREEHBGGF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1CC(=O)N(C1)CC(=O)N
CACTVS 3.352NC(=O)CN1CCCC1=O
FormulaC6 H10 N2 O2
Name2-(2-oxopyrrolidin-1-yl)acetamide
ChEMBLCHEMBL36715
DrugBankDB09210
ZINCZINC000003812874
PDB chain3lsf Chain E Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3lsf Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
Resolution1.851 Å
Binding residue
(original residue number in PDB)		D216 S217
Binding residue
(residue number reindexed from 1)		D213 S214
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3lsf, PDBe:3lsf, PDBj:3lsf
PDBsum3lsf
PubMed20163115
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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