Structure of PDB 2p1n Chain E Binding Site BS03

Receptor Information
>2p1n Chain E (length=571) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFPEEVLEHVFSFIQLDKDRNSVSLVCKSWYEIERWCRRKVFIGNCYAVS
PATVIRRFPKVRSVELKGKPHFADFNLVPDGWGGYVYPWIEAMSSSYTWL
EEIRLKRMVVTDDCLELIAKSFKNFKVLVLSSCEGFSTDGLAAIAATCRN
LKELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSALERLV
TRCPNLKSLKLNRAVPLEKLATLLQRAPQLEELGTGGYTAEVRPDVYSGL
SVALSGCKELRCLSGFWDAVPAYLPAVYSVCSRLTTLNLSYATVQSYDLV
KLLCQCPKLQRLWVLDYIEDAGLEVLASTCKDLRELRVFPSEPFVMEPNV
ALTEQGLVSVSMGCPKLESVLYFCRQMTNAALITIARNRPNMTRFRLCII
EPKAPDYLTLEPLDIGFGAIVEHCKDLRRLSLSGLLTDKVFEYIGTYAKK
MEMLSVAFAGDSDLGMHHVLSGCDSLRKLEIRDCPFGDKALLANASKLET
MRSLWMSSCSVSFGACKLLGQKMPKLNVEVIDERGAPDSRPESCPVERVF
IYRTVAGPRFDMPGFVWNMDQ
Ligand information
Ligand IDCFA
InChIInChI=1S/C8H6Cl2O3/c9-5-1-2-7(6(10)3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)
InChIKeyOVSKIKFHRZPJSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC(=O)COc1ccc(Cl)cc1Cl
OpenEye OEToolkits 1.5.0c1cc(c(cc1Cl)Cl)OCC(=O)O
ACDLabs 10.04Clc1cc(Cl)ccc1OCC(=O)O
FormulaC8 H6 Cl2 O3
Name(2,4-DICHLOROPHENOXY)ACETIC ACID;
2,4-DICHLOROPHENOXYACETIC ACID
ChEMBLCHEMBL367623
DrugBank
ZINCZINC000000057143
PDB chain2p1n Chain E Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2p1n Mechanism of auxin perception by the TIR1 ubiquitin ligase
Resolution2.5 Å
Binding residue
(original residue number in PDB)		L378 R403 L404 C405 S438 L439 V463
Binding residue
(residue number reindexed from 1)		L371 R396 L397 C398 S431 L432 V456
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0010011 auxin binding
GO:0038198 auxin receptor activity
Biological Process
GO:0006952 defense response
GO:0009733 response to auxin
GO:0009734 auxin-activated signaling pathway
GO:0009873 ethylene-activated signaling pathway
GO:0010152 pollen maturation
GO:0010311 lateral root formation
GO:0016036 cellular response to phosphate starvation
GO:0016567 protein ubiquitination
GO:0048443 stamen development
Cellular Component
GO:0005634 nucleus
GO:0019005 SCF ubiquitin ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2p1n, PDBe:2p1n, PDBj:2p1n
PDBsum2p1n
PubMed17410169
UniProtQ570C0|TIR1_ARATH Protein TRANSPORT INHIBITOR RESPONSE 1 (Gene Name=TIR1)

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