Structure of PDB 8qpk Chain D Binding Site BS03

Receptor Information
>8qpk Chain D (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEK
VKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNK
INWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY
Ligand information
>8qpk Chain 6 (length=43) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuggaauacagagaagauuagcauggccccugcgcaaggauga
...........................................
Receptor-Ligand Complex Structure
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PDB8qpk Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution4.2 Å
Binding residue
(original residue number in PDB)		R124 K125 G126
Binding residue
(residue number reindexed from 1)		R123 K124 G125
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005829 cytosol
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qpk, PDBe:8qpk, PDBj:8qpk
PDBsum8qpk
PubMed38778104
UniProtP83876|TXN4A_HUMAN Thioredoxin-like protein 4A (Gene Name=TXNL4A)

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