BioLiP

Receptor Information

>8ipm Chain D (length=282) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAY
ALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSM
QLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRT
YGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQ
RSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALSFHSLE
DRIVKRFLLGISMLMWELIHKKVAKLRAAIKL

Ligand ID

SFG

InChI

InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1

InChIKey

LMXOHSDXUQEUSF-YECHIGJVSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.7.0	c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)C[C@H](CC[C@@H](C(=O)O)N)N)O)O)N
OpenEye OEToolkits 1.7.0	c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O)N
CACTVS 3.370	N[CH](CC[CH](N)C(O)=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
CACTVS 3.370	N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
ACDLabs 12.01	O=C(O)C(N)CCC(N)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O

Formula

C15 H23 N7 O5

Name

SINEFUNGIN;
ADENOSYL-ORNITHINE

PDB chain

8ipm Chain D Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8ipm Structural insights reveal the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12S rRNA by methyltransferase METTL15
Resolution	3.1 Å
Binding residue (original residue number in PDB)	T27 F28 G29 G32 H33 D50 R51 F77 D100 S104 E226
Binding residue (residue number reindexed from 1)	T21 F22 G23 G26 H27 D44 R45 F71 D94 S98 E220
Annotation score	3

Enzyme Commision number

2.1.1.-

	Molecular Function
GO:0008168	methyltransferase activity

PDB	RCSB:8ipm, PDBe:8ipm, PDBj:8ipm
PDBsum	8ipm
PubMed	38291322
UniProt	A6NJ78\|MET15_HUMAN 12S rRNA N4-methylcytidine (m4C) methyltransferase (Gene Name=METTL15)

[Back to BioLiP]

Structure of PDB 8ipm Chain D Binding Site BS03