Structure of PDB 8i24 Chain D Binding Site BS03

Receptor Information
>8i24 Chain D (length=1152) Species: 637887 (Acetivibrio thermocellus DSM 1313) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNFDSIRIGLASPEKIREWSRGEVKKPETINYRTLKPERDGLFCERIFGP
QKDWECHCGKYKRIRYKGIVCDRCGVEVTRSKVRRERMGHIELAAPVSHI
WYFKGIPSRMGLLLDMSPRALEKILYFAAYVVIDPGQTPLSKKQILSEKE
YRDSLEKFGPKFRAGMGAEAVRELLQEINLDELSAELREEIKQSTGQKRV
RAIKRLEVVEAFRQSQNKPEWMILDVIPVIPPELRPMVQLDGGRFATSDL
NDLYRRVINRNNRLKRLLDLGAPDIIVRNEKRMLQEAVDALIDNGRRGRP
VTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKIYQ
CGLPKEMALELFKPFVMKKLVNDGLAHNIKSAKRMVERVRNEVWDVLEEV
IKEHPVLLNRAPTLHRLGIQAFEPVLVEGRALKLHPLVCTAYNADFDGDQ
MAIHVPLSAEAQAEARFLMLSANNLLKPQDGKPVAVPTQDMVLGSYYLTI
LKEGAKGEGRVFTSMDEAVMAYDNGEIELHSKIKVRMKRVVDGVEKSKII
ETTLGRLIFNEAIPQDLGFVDRSDPDKIFDLEVDFLVGKNELKKIIDKSI
KVHGTTKTAILLDKIKELGFKYSTKGAITISISDMVIPEVKAKYIKETEE
KIEKITKQYKRGLISDEERYNSVIAAWTEASENITRALINNLDRFNPVYM
MSQSGARGNINQIKQLAGMRGLMADTSGKTIEFPIKANFREGLTVMEFFI
STHGARKGLADTALRTADSGYLTRRLVDVSQDVIVRETDCGTRKGIEVTD
IKDGNEVIEELSERIIGRYPVGNIVHPETGEIIVEAGRMITDQDAEKIVK
AGIKKVRIRSVLTCHSEYGVCAKCYGANLATGEECNVGEAVGIIAAQSIG
EPGTQLTMRTGEDITQGLPRVEELFEARKPKGLAIISEIKGTVKISETKK
KREIVVTSEDGETRSYLIPYGSRIKVSDGDQVEAGDELTEGSVNPHDILK
IKGVEAVQTYLVHEVQKVYRMQGVDINDKHIEVIVRQMLRKVKVEDPGDT
SLLPGGLVDVFDFEEENAKAIAEGKKPAVAKRALLGITKAALATDSFLSA
ASFQETTRVLTEAAIKGKVDPLVGLKENVIIGKLIPAGTGMSRYKDITIS
TV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8i24 Chain D Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8i24 Structure of the transcription open complex of distinct sigmaI factors
Resolution3.36 Å
Binding residue
(original residue number in PDB)		C891 C901
Binding residue
(residue number reindexed from 1)		C864 C874
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i24, PDBe:8i24, PDBj:8i24
PDBsum8i24
PubMed37833284
UniProtA3DIZ5|RPOC_ACET2 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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