Structure of PDB 7z42 Chain D Binding Site BS03

Receptor Information
>7z42 Chain D (length=715) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYEQNLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYL
ADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLS
NESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQT
ISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKL
TWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAK
ECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQ
KTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEM
NLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMK
YVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHL
RGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYC
RVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGD
RVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAE
SRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWL
GFEKEGSKVLESVDE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z42 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution2.418 Å
Binding residue
(original residue number in PDB)		G596 Y597 D598 D607 R608 V609
Binding residue
(residue number reindexed from 1)		G589 Y590 D591 D600 R601 V602
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z42, PDBe:7z42, PDBj:7z42
PDBsum7z42
PubMed35605026
UniProtQ5V8Z9

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