Structure of PDB 7t3v Chain D Binding Site BS03

Receptor Information

>7t3v Chain D (length=517) Species: 5833 (Plasmodium falciparum)

ASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNN
PGKENGPVKISSKVNDKQVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNS
VAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNL
FRFFLETLFYEYMTDERFKSTDKNMEYIKHLGVYINNADTYKEEVEKARV
YYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEEL
KMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLK
AAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSK
NSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIAT
LTGAMLYSLGTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRAT
LNSKYADINQISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKAR
KPKGFGVRLLTEFVLND

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7t3v Chain D Residue 704

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7t3v A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): D379 D459 E461
• Binding residue (residue number reindexed from 1): D293 D373 E375
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.
  3.4.13.-

Gene Ontology

Molecular Function

• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7t3v, PDBe:7t3v, PDBj:7t3v
• PDBsum: 7t3v
• PubMed: 35691342
• UniProt: Q8IL11|AMPL_PLAF7 Leucine aminopeptidase (Gene Name=LAP)