Structure of PDB 7sgl Chain D Binding Site BS03

Receptor Information
>7sgl Chain D (length=406) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRR
LECSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEAS
GEKEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELL
HSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYH
VVWLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRN
TQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRK
TNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDK
VVEILKPLCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIP
LRHKVP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7sgl Chain D Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7sgl Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H33 H35 H115 D136
Binding residue
(residue number reindexed from 1)		H33 H35 H115 D136
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0003684 damaged DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0035312 5'-3' DNA exonuclease activity
Biological Process
GO:0000723 telomere maintenance
GO:0002250 adaptive immune response
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0010212 response to ionizing radiation
GO:0030183 B cell differentiation
GO:0033151 V(D)J recombination
GO:0036297 interstrand cross-link repair
GO:0051276 chromosome organization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0070419 nonhomologous end joining complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sgl, PDBe:7sgl, PDBj:7sgl
PDBsum7sgl
PubMed34936881
UniProtQ96SD1|DCR1C_HUMAN Protein artemis (Gene Name=DCLRE1C)

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