Structure of PDB 7l7b Chain D Binding Site BS03

Receptor Information
>7l7b Chain D (length=1148) Species: 2044939 (Clostridia bacterium) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELNNFESIKIALASPEKIRQWSRGEVKKPETINYRTLKPEKDGLFCERIF
GPQKDWECHCGKYRRVRYKGVVCDRCGVEVTKSKVRRERMGHIELAAPMS
HIWYFKGIPSRMGLLLDMSPRSLEKILYFASYVVVDPGETGLNEKQLLTE
KEYRTALEKYGYTFTVGMGAEAVKTLLQNIDLEQQSKDLRAELKDSTGQK
KVRTIRRLEVVEAFKKSGNKPEWMILDAIPVIPPDLRPMVQLDGGRFATS
DLNDLYRRVINRNNRLKRLLELGAPDIIVRNEKRMLQEAVDALIDNGRRG
RPVTGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKF
YQCGLPKKMALELFKPFVMDKLVKEGYAHNIKSAKSIVEKVKPEVWDVLE
DVIKSHPVLLNRAPTLHRLGIQAFEPILVEGKAIKLHPLVCTAYNADFDG
DQMAVHVPLSVEAQAEARFLMLSVNNILAPKDGSPITTPSQDMVLGCYYL
TIEAQDGAKGTGMVFKDFNELLLAYYNKSVHLHALVKLKVTLEDGRSSLV
ESTVGRFIFNENIPQDLGFVDRKENPFALEVDFLADKKSLGKIIDKCFRK
HGNTETAELLDYIKALGFKYSTLGGITVAVDDMSVPEEKKVFIAEAEAKV
DKYEKAYRRGLISDEERYEKVIETWTETTDKVTDALMGGLDRLNNIYIMA
HSGARGSKNQIRQLAGMRGLMANASGKTVEIPVKSNFREGLSVLEYFTSS
HGARKGLADTAIRTAESGYLTRRLVDVSQDVIVREIDCGTEDTTEIYAIK
EGNEVIEEIYDRIVGRYTIDPILNPETGEVIVEADSMIQEDEAETIVALG
IEKIRIRTVLNCKTNHGVCSKCYGRNLATGKEVNIGEAVGIIAAQSIGEP
GTQLTMRTFTQGLPRVEELFEARKPKGLAVITEVSGRVEIDETGKRKEVN
VIPEEGETQTYVIPYGSRLKVKQGQMLEAGDPLTQGFINPHDIVRVNGVK
GVQEYIVKEVQRVYRLQGVDVNDKHIEVIVRQMLSKVKVEDPGDTDLLPG
GYEDVLTFNECNKDAIDKGLRPAVAKRVLLGITKASLATDSFLSAASFQE
TTRVLTEAAIKGKEDHLIGLKENVILGKLIPAGTGMKKYRNIAVEKIE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7l7b Chain D Residue 1403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7l7b Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile.
Resolution3.26 Å
Binding residue
(original residue number in PDB)		D449 D451 D453
Binding residue
(residue number reindexed from 1)		D447 D449 D451
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7l7b, PDBe:7l7b, PDBj:7l7b
PDBsum7l7b
PubMed35388215
UniProtQ18CF3|RPOC_CLOD6 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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