Structure of PDB 7jk5 Chain D Binding Site BS03

Receptor Information

>7jk5 Chain D (length=441) Species: 7227 (Drosophila melanogaster)

PEADRELVSIRRFLKERLQRDYTTLRGYAKERSNVRLLLQRTAEMGESNS
LLLLGPRGSGKTTLINSVLADLLPNKSFGENTLIVHLDGNLHTDDRVALK
SITVQMQLENAADGKVFGSFAENLAFLLQCLKAGGKHSKSVIFILEEFDL
FCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRLDVIELLEKRVKSRFSHR
QVFLFPSLRRFEDYVDLCRDLLSLPTGNSLLLAAEKIYNLQNIYFSRNHF
DPGEYGFSPRLRDAWNKQICKVLATQQARSTLQALHDFDISEAYLKNFLF
RLVAHLRPQSPHITAEKMAAVGSQFEGDDKIELLCGLSVLELCLIIAIKH
HSQIYDRDSFNFEIIYARFSKFAKVSTTMQAVERSIVLKAFEHLRIAELI
MPLTVQKEFEMHKLALTYSQIHHCMQRYQALPTEVAQWAQS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7jk5 Chain D Residue 902

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7jk5 Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): T63 E147
• Binding residue (residue number reindexed from 1): T62 E146
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003688 DNA replication origin binding
• GO:0005515 protein binding
• GO:0016887 ATP hydrolysis activity
• GO:0043021 ribonucleoprotein complex binding

Biological Process

• GO:0006260 DNA replication
• GO:0006270 DNA replication initiation

Cellular Component

• GO:0000808 origin recognition complex
• GO:0005634 nucleus
• GO:0005643 nuclear pore
• GO:0005664 nuclear origin of replication recognition complex

External links

• PDB: RCSB:7jk5, PDBe:7jk5, PDBj:7jk5
• PDBsum: 7jk5
• PubMed: 32848132
• UniProt: Q9W102