Structure of PDB 7ckq Chain D Binding Site BS03

Receptor Information
>7ckq Chain D (length=1137) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTK
DWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVSHIWY
FKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYR
AYLDKYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRA
IKRLEVLEAFRNSGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLND
LYRRVINRNNRLKRLLDLGAPSIIVQNEKRMLQEAVDALIDNGRRGRPVT
GPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPHLKMYQCG
LPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIERVQPEVWDVLESVIK
EHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADFDGDQMA
VHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLER
AGAVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLQRSKLLITTVGK
LVFNEILPESFPYMNEPTKSNIEEDVKAVIAQQPINAPFKKGILGKIIAE
IFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEA
QSKVDNVMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPI
YMMSDSGARGNASNFTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEY
FISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIIRETDCGTDRGILA
KPLKEGTETIERLEERLIGRFARKQVKHPETGEVLVNENELIDEDKALEI
VEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVEVGEAVGIIAAQS
IGEPGTQLTGLPRIQELFEARNPATITEIDGTVVEINEVRDKQQEIVVQG
AVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSIDPKELLKVTDLTTVQE
YLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVGDTDVLPGTLLDIHQ
FTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVLTD
AAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7ckq Chain D Residue 1501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ckq The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		D449 D451
Binding residue
(residue number reindexed from 1)		D443 D445
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ckq, PDBe:7ckq, PDBj:7ckq
PDBsum7ckq
PubMed33293519
UniProtP37871|RPOC_BACSU DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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