Structure of PDB 6zxm Chain D Binding Site BS03

Receptor Information

>6zxm Chain D (length=293) Species: 456481 (Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)')

RKILIIEDSELQRKLLSRWVSKNGYIAIEAESISVAREKIISESIDVVLL
DWELPDGNGIDLISDILSTSPVGWLPIIMVTGHTEPEYFKIAIEAGATDY
ITKPAKEIELLARIFSALRIKALHDQLRETAIRDVMTGLYNRRYMEERIE
QEFQRCKRHDSLLSMAMIDIDKFKNINDTYGHEIGDQVIKQLAHELKTSF
RKSDIISRFGGEEFVILFPETGVVDATRILDRVRENVSKLEMKSDTDQIF
HFTFSGGVAGGDLSDIQSNQELLKIADKNLYEAKSSGRNQIIS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6zxm Chain D Residue 303

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zxm Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): E12 D13 D56
• Binding residue (residue number reindexed from 1): E7 D8 D51
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0046872 metal ion binding
• GO:0052621 diguanylate cyclase activity

Biological Process

• GO:0000160 phosphorelay signal transduction system
• GO:0043709 cell adhesion involved in single-species biofilm formation
• GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:6zxm, PDBe:6zxm, PDBj:6zxm
• PDBsum: 6zxm
• PubMed: 33846343
• UniProt: B0SUI1